Molecule Details
InChIKeyOWDRQHVEJIYVOI-UHFFFAOYSA-N
Compound Name1-(4-Chloro-2-methylphenyl)-3-[(2-hydroxy-2,2-diphenylacetyl)amino]thiourea
Canonical SMILESCc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)47
Pfam Stratification Cross-Family
Avg pChEMBL6.46
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (47)
Target Gene Organism Category Pfam pChEMBL Type Source
O00418 EEF2K Homo sapiens Human PF02816 7.1 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 7.1 Ki ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 7.1 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 7.0 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 7.0 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.9 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 6.9 Ki ChEMBL
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 6.8 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.8 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.7 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q16644 MAPKAPK3 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 6.6 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q9Y6M4 CSNK1G3 Homo sapiens Human PF12605 PF00069 6.5 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.4 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.4 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q96KB5 PBK Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
P53350 PLK1 Homo sapiens Human PF00069 PF00659 6.3 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.3 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.3 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.3 Ki ChEMBL
Q9P1W9 PIM2 Homo sapiens Human PF00069 6.3 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.2 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.2 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P15735 PHKG2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.1 Ki ChEMBL
P51957 NEK4 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.1 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.1 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.0 Ki ChEMBL