Molecule Details
| InChIKey | OUSFTKFNBAZUKL-UHFFFAOYSA-N |
|---|---|
| Compound Name | N-(5-(((5-(1,1-Dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide |
| Canonical SMILES | CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 |
| Clinical Status | Clinical Multi-Target |
| Targets (Human+Pathogen) | 58 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.84 |
| Source | BindingDB;ChEMBL;TTD_MultiTarget |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB05969 |
|---|---|
| Drug Name | SNS-032 |
| CAS Number | 345627-80-7 |
| Groups | investigational |
| ATC Codes | nan |
| Description | nan |
Categories: Sulfur Compounds
Cross-references: BindingDB: 5931 ChEBI: 91399 CHEMBL296468 ChemSpider: 2291614 PDB: 56H ZINC: ZINC000003816409
Target Activities (58)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O76039 | CDKL5 | Homo sapiens | Human | PF00069 | 8.8 | Kd | ChEMBL;BindingDB |
| O60563 | CCNT1 | Homo sapiens | Human | PF00134 PF21797 | 8.4 | IC50 | ChEMBL;BindingDB |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 8.3 | Kd | BindingDB |
| P50750 | CDK9 | Homo sapiens | Human | PF00069 | 8.2 | IC50 | ChEMBL;BindingDB |
| Q00536 | CDK16 | Homo sapiens | Human | PF00069 | 8.2 | Kd | ChEMBL;BindingDB |
| Q00537 | CDK17 | Homo sapiens | Human | PF00069 | 7.9 | Kd | ChEMBL;BindingDB |
| P78396 | CCNA1 | Homo sapiens | Human | PF02984 PF00134 PF16500 | 7.7 | IC50 | ChEMBL |
| Q14004 | CDK13 | Homo sapiens | Human | PF00069 | 7.6 | Kd | ChEMBL;BindingDB |
| P49840 | GSK3A | Homo sapiens | Human | PF00069 | 7.5 | Kd | ChEMBL;BindingDB |
| P49841 | GSK3B | Homo sapiens | Human | PF00069 | 7.4 | Kd | ChEMBL;BindingDB |
| P20248 | CCNA2 | Homo sapiens | Human | PF02984 PF00134 PF16500 | 7.4 | IC50 | ChEMBL |
| P24941 | CDK2 | Homo sapiens | Human | PF00069 | 7.4 | pIC50 | TTD_MultiTarget |
| Q92772 | CDKL2 | Homo sapiens | Human | PF00069 | 7.4 | Kd | ChEMBL;BindingDB |
| Q07002 | CDK18 | Homo sapiens | Human | PF00069 | 7.4 | Kd | ChEMBL;BindingDB |
| O96020 | CCNE2 | Homo sapiens | Human | PF02984 PF00134 | 7.3 | IC50 | ChEMBL |
| P24864 | CCNE1 | Homo sapiens | Human | PF02984 PF00134 | 7.3 | IC50 | ChEMBL |
| Q9UQ88 | CDK11A | Homo sapiens | Human | PF00069 | 7.3 | Kd | ChEMBL;BindingDB |
| Q00526 | CDK3 | Homo sapiens | Human | PF00069 | 7.2 | Kd | ChEMBL;BindingDB |
| P50613 | CDK7 | Homo sapiens | Human | PF00069 | 7.2 | IC50 | ChEMBL;BindingDB |
| P51946 | CCNH | Homo sapiens | Human | PF16899 PF00134 | 7.2 | IC50 | ChEMBL;BindingDB |
| P51948 | MNAT1 | Homo sapiens | Human | PF25811 PF06391 PF17121 | 7.2 | IC50 | ChEMBL |
| P21127 | CDK11B | Homo sapiens | Human | PF00069 | 7.0 | Kd | ChEMBL;BindingDB |
| Q8TD08 | MAPK15 | Homo sapiens | Human | PF00069 | 6.9 | Kd | ChEMBL;BindingDB |
| P06493 | CDK1 | Homo sapiens | Human | PF00069 | 6.9 | pIC50 | TTD_MultiTarget |
| P11802 | CDK4 | Homo sapiens | Human | PF00069 | 6.9 | pIC50 | TTD_MultiTarget |
| Q00534 | CDK6 | Homo sapiens | Human | PF00069 | 6.8 | Kd | ChEMBL |
| Q9UPZ9 | CILK1 | Homo sapiens | Human | PF00069 | 6.8 | Kd | ChEMBL;BindingDB |
| Q14680 | MELK | Homo sapiens | Human | PF02149 PF00069 PF21594 | 6.8 | Ki | ChEMBL |
| Q9NYV4 | CDK12 | Homo sapiens | Human | PF00069 | 6.8 | Kd | ChEMBL |
| P49336 | CDK8 | Homo sapiens | Human | PF00069 | 6.7 | Ki | ChEMBL |
| Q9Y463 | DYRK1B | Homo sapiens | Human | PF00069 | 6.7 | Kd | ChEMBL;BindingDB |
| Q9NRP7 | STK36 | Homo sapiens | Human | PF13646 PF00069 | 6.6 | Kd | ChEMBL;BindingDB |
| Q00535 | CDK5 | Homo sapiens | Human | PF00069 | 6.5 | IC50 | ChEMBL;BindingDB |
| Q13627 | DYRK1A | Homo sapiens | Human | PF00069 | 6.5 | Kd | ChEMBL;BindingDB |
| Q15078 | CDK5R1 | Homo sapiens | Human | PF03261 | 6.5 | IC50 | ChEMBL;BindingDB |
| O14936 | CASK | Homo sapiens | Human | PF00625 PF02828 PF00595 PF00069 PF07653 | 6.4 | Kd | ChEMBL;BindingDB |
| P49759 | CLK1 | Homo sapiens | Human | PF00069 | 6.4 | Kd | ChEMBL;BindingDB |
| Q9UEE5 | STK17A | Homo sapiens | Human | PF00069 | 6.4 | Kd | ChEMBL;BindingDB |
| P15735 | PHKG2 | Homo sapiens | Human | PF00069 | 6.3 | Kd | ChEMBL;BindingDB |
| O95067 | CCNB2 | Homo sapiens | Human | PF02984 PF00134 | 6.3 | IC50 | ChEMBL |
| P14635 | CCNB1 | Homo sapiens | Human | PF02984 PF00134 | 6.3 | IC50 | ChEMBL |
| Q8WWL7 | CCNB3 | Homo sapiens | Human | PF02984 PF00134 | 6.3 | IC50 | ChEMBL |
| Q16659 | MAPK6 | Homo sapiens | Human | PF00069 | 6.3 | Kd | ChEMBL;BindingDB |
| Q9H2K8 | TAOK3 | Homo sapiens | Human | PF00069 | 6.2 | Kd | ChEMBL;BindingDB |
| Q13164 | MAPK7 | Homo sapiens | Human | PF00069 | 6.2 | Kd | ChEMBL;BindingDB |
| O94921 | CDK14 | Homo sapiens | Human | PF00069 | 6.2 | Kd | ChEMBL;BindingDB |
| Q96Q40 | CDK15 | Homo sapiens | Human | PF00069 | 6.1 | Kd | ChEMBL;BindingDB |
| O94806 | PRKD3 | Homo sapiens | Human | PF00130 PF00169 PF00069 PF25525 | 6.1 | Kd | ChEMBL;BindingDB |
| Q7L7X3 | TAOK1 | Homo sapiens | Human | PF00069 | 6.1 | Ki | ChEMBL |
| Q9HAZ1 | CLK4 | Homo sapiens | Human | PF00069 | 6.1 | Kd | ChEMBL;BindingDB |
| P24385 | CCND1 | Homo sapiens | Human | PF02984 PF00134 | 6.0 | IC50 | ChEMBL |
| P30279 | CCND2 | Homo sapiens | Human | PF02984 PF00134 | 6.0 | IC50 | ChEMBL |
| P30281 | CCND3 | Homo sapiens | Human | PF02984 PF00134 | 6.0 | IC50 | ChEMBL |
| P49674 | CSNK1E | Homo sapiens | Human | PF00069 | 6.0 | Kd | ChEMBL;BindingDB |
| Q9BWU1 | CDK19 | Homo sapiens | Human | PF00069 | 6.0 | Kd | ChEMBL;BindingDB |
| Q9H1R3 | MYLK2 | Homo sapiens | Human | PF00069 | 6.0 | Kd | ChEMBL;BindingDB |
| P48729 | CSNK1A1 | Homo sapiens | Human | PF00069 | 6.0 | Kd | ChEMBL;BindingDB |
| Q8N568 | DCLK2 | Homo sapiens | Human | PF03607 PF00069 | 6.0 | Kd | ChEMBL;BindingDB |