Molecule Details
InChIKeyOUJZYQBEFNDJQN-UHFFFAOYSA-N
Compound Name4-[[6-chloro-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]cyclohexan-1-ol
Canonical SMILESOC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)71
Pfam Stratification Cross-Family
Avg pChEMBL6.76
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (71)
Target Gene Organism Category Pfam pChEMBL Type Source
O00311 CDC7 Homo sapiens Human PF00069 9.0 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 8.4 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 8.1 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 7.9 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 7.9 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 7.7 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.7 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q02750 MAP2K1 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 7.5 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 7.5 Ki ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 7.3 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 7.3 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 7.3 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.3 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.2 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.2 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 7.1 Ki ChEMBL
Q02779 MAP3K10 Homo sapiens Human PF07714 PF14604 7.1 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.1 Ki ChEMBL
O96013 PAK4 Homo sapiens Human PF00786 PF00069 7.0 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 7.0 Ki ChEMBL
Q04759 PRKCQ Homo sapiens Human PF00130 PF21494 PF00069 PF00433 7.0 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 7.0 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.9 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.9 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.8 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.8 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.7 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 6.7 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.7 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.7 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.7 Ki ChEMBL
P05129 PRKCG Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.6 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.6 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9P1W9 PIM2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.5 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.5 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.5 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 6.5 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.4 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.4 Ki ChEMBL
P41743 PRKCI Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.4 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.4 Ki ChEMBL
Q96L34 MARK4 Homo sapiens Human PF02149 PF00069 PF00627 6.4 Ki ChEMBL
Q9H0K1 SIK2 Homo sapiens Human PF00069 PF23312 6.4 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.3 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 Ki ChEMBL
Q05513 PRKCZ Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.2 Ki ChEMBL
Q13153 PAK1 Homo sapiens Human PF00786 PF00069 6.2 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.2 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.1 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P51957 NEK4 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.1 Ki ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.0 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.0 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.0 Ki ChEMBL