4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol — MultiTargetDB

Molecule Details

InChIKey	`OTMLAWRVLMYMDF-UHFFFAOYSA-N`
Compound Name	4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol
Canonical SMILES	`CNc1nc(C)c(-c2ccnc(Nc3ccc(O)cc3)n2)s1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	7.16
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

2D structure

Activity Profile

DrugBank Annotations

DrugBank ID	DB04407
Drug Name	4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol
CAS Number	nan
Groups	experimental
ATC Codes	nan
Description	nan

Cross-references: BindingDB: 8054 CHEMBL47590 ChemSpider: 394905 PDB: CK6 PubChem:447960 PubChem:46505843 ZINC: ZINC000002047390

Target Activities (3)

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P20248	CCNA2	Homo sapiens	Human	PF02984 PF00134 PF16500	7.2	Ki	ChEMBL
P24941	CDK2	Homo sapiens	Human	PF00069	7.2	Ki	ChEMBL;BindingDB
P11802	CDK4	Homo sapiens	Human	PF00069	7.2	pIC50	TTD_MultiTarget

DrugBank Target Actions (1)

Target	Gene	Target Name	Action	Type
P24941	CDK2	Cyclin-dependent kinase 2	binder	targets