3-[(4-morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[5,4-d]pyrazole-5-carboxamide

InChIKey	`ORWIYCURPDKSBI-XMMPIXPASA-N`
Compound Name	3-[(4-morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[5,4-d]pyrazole-5-carboxamide
Canonical SMILES	`O=C(Nc1n[nH]c2cc(C(=O)N[C@H](CN3CCCC3)c3ccccc3)sc12)c1ccc(N2CCOCC2)cc1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	15
Pfam Stratification	Cross-Family
Avg pChEMBL	7.06
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	7.8	IC50	ChEMBL;BindingDB
O14965	AURKA	Homo sapiens	Human	PF00069	7.7	IC50	ChEMBL;BindingDB
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	7.7	IC50	ChEMBL;BindingDB
P10721	KIT	Homo sapiens	Human	PF00047 PF07714	7.5	IC50	ChEMBL;BindingDB
P18505	GABRB1	Homo sapiens	Human	PF02931 PF02932	7.4	pIC50	TTD_MultiTarget
O75716	STK16	Homo sapiens	Human	PF00069	7.3	pIC50	TTD_MultiTarget
Q96GD4	AURKB	Homo sapiens	Human	PF00069	7.3	IC50	ChEMBL;BindingDB
Q9UQB9	AURKC	Homo sapiens	Human	PF00069	7.2	IC50	ChEMBL;BindingDB
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	7.0	IC50	ChEMBL;BindingDB
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.8	IC50	ChEMBL;BindingDB
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	6.7	IC50	ChEMBL;BindingDB
P17612	PRKACA	Homo sapiens	Human	PF00069	6.5	IC50	ChEMBL;BindingDB
Q9P289	STK26	Homo sapiens	Human	PF20929 PF00069	6.4	IC50	ChEMBL;BindingDB
O96013	PAK4	Homo sapiens	Human	PF00786 PF00069	6.3	IC50	ChEMBL;BindingDB
Q15118	PDK1	Homo sapiens	Human	PF10436 PF02518	6.1	IC50	ChEMBL;BindingDB