Molecule Details
InChIKeyOOQJIJYKWXLQNC-UHFFFAOYSA-N
Compound Name4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine
Canonical SMILESc1cc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)ccn1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)16
Pfam Stratification Cross-Family
Avg pChEMBL6.97
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (16)
Target Gene Organism Category Pfam pChEMBL Type Source
P36888 FLT3 Homo sapiens Human PF00047 PF07714 9.0 IC50 ChEMBL;BindingDB
Q02161 RHD Homo sapiens Human PF00909 7.6 pIC50 TTD_MultiTarget
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.5 IC50 ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.5 IC50 ChEMBL;BindingDB
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.3 IC50 ChEMBL;BindingDB
Q9BUB5 MKNK1 Homo sapiens Human PF00069 6.9 IC50 ChEMBL;BindingDB
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.7 IC50 ChEMBL;BindingDB
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 6.6 IC50 ChEMBL;BindingDB
O43741 PRKAB2 Homo sapiens Human PF16561 PF04739 6.5 IC50 ChEMBL
P54619 PRKAG1 Homo sapiens Human PF00571 6.5 IC50 ChEMBL
P54646 PRKAA2 Homo sapiens Human PF16579 PF21147 PF00069 6.5 IC50 ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.5 IC50 ChEMBL
Q9UGI9 PRKAG3 Homo sapiens Human PF00571 6.5 IC50 ChEMBL
Q9UGJ0 PRKAG2 Homo sapiens Human PF00571 6.5 IC50 ChEMBL
Q9Y478 PRKAB1 Homo sapiens Human PF16561 PF04739 6.5 IC50 ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.5 IC50 ChEMBL;BindingDB