Molecule Details
InChIKeyONBSHRSJOPSEGS-INIZCTEOSA-N
Canonical SMILESCS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)C(F)(F)C2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL8.31
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB16055
Drug NamePT-2385
CAS Number1672665-49-4
Groups investigational
ATC Codes nan
DescriptionPT-2385 is under investigation in clinical trial NCT03108066 (PT2385 for the Treatment of Von Hippel-lindau Disease-associated Clear Cell Renal Cell Carcinoma).

Categories: Indenes Sulfur Compounds
Cross-references: CHEMBL4173075 ChemSpider: 35308226 PDB: 79A ZINC: ZINC000230453533
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P27540 ARNT Homo sapiens Human PF00010 PF00989 PF14598 8.7 IC50 ChEMBL
Q99814 EPAS1 Homo sapiens Human PF23171 PF11413 PF08778 PF00989 PF14598 7.9 IC50 ChEMBL;BindingDB
DrugBank Target Actions (2)
Target Gene Target Name Action Type
Q16665 HIF1A Hypoxia-inducible factor 1-alpha inhibitor targets
Q99814 EPAS1 Endothelial PAS domain-containing protein 1 inhibitor targets