Molecule Details
| InChIKey | OLVCFLKTBJRLHI-AXAPSJFSSA-N |
|---|---|
| Canonical SMILES | Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](O)c3ccccc3)[C@H]2SC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.43 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01326 |
|---|---|
| Drug Name | Cefamandole |
| CAS Number | 34444-01-4 |
| Groups | approved withdrawn |
| ATC Codes | J01DC03 |
| Description | Cefamandole is also known as cephamandole. It is a parenterally administered broad-spectrum cephalosporin antibiotic. It is generally formulated as a formate ester, [cefamandole nafate]. It is no longer marketed in the United States. |
Categories: Amides Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Cephalosporins Heterocyclic Compounds, Fused-Ring Lactams Nephrotoxic agents OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors Second-Generation Cephalosporins Sulfur Compounds Thiazines beta-Lactams
Cross-references: BindingDB: 50350468 ChEBI: 3480 CHEMBL1146 ChemSpider: 401748 Drugs Product Database (DPD): 2121 C06879 D02344 PDB: SMX PharmGKB: PA448837 PubChem:456255 PubChem:46508882 RxCUI: 2178 Therapeutic Targets Database: DAP000448 Wikipedia: Cefamandole ZINC: ZINC000003830394
Target Activities (2)
DrugBank Target Actions (5)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q70KI2 | Q70KI2 | Penicillin-binding protein 2 | inhibitor | targets |
| Q4U2R8 | SLC22A6 | Solute carrier family 22 member 6 | inhibitor | transporters |
| Q8TCC7 | SLC22A8 | Organic anion transporter 3 | inhibitor | transporters |
| Q9NSA0 | SLC22A11 | Solute carrier family 22 member 11 | inhibitor | transporters |
| Q9Y694 | Q9Y694 | Solute carrier family 22 member 7 | inhibitor | transporters |