Molecule Details
InChIKeyOLVBAUVSICCWEJ-UHFFFAOYSA-N
Compound NameN-[(3-fluorophenyl)methyl]-9-(4-hydroxy-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepine-3-carboxamide
Canonical SMILESCOc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)39
Pfam Stratification Cross-Family
Avg pChEMBL6.5
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (39)
Target Gene Organism Category Pfam pChEMBL Type Source
Q00535 CDK5 Homo sapiens Human PF00069 7.6 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 7.5 Ki ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 7.2 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 7.0 Ki ChEMBL
Q96RG2 PASK Homo sapiens Human PF13426 PF00069 6.9 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.7 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.7 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.7 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.6 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 6.6 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.6 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.6 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.5 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.5 Ki ChEMBL
Q9P1W9 PIM2 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P15735 PHKG2 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.4 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.4 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 6.4 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.3 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.3 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.3 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.2 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q9UHD2 TBK1 Homo sapiens Human PF00069 PF18394 PF18396 6.2 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.1 Ki ChEMBL
Q96KB5 PBK Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q96PF2 TSSK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.1 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.0 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.0 Ki ChEMBL
Q8TDC3 BRSK1 Homo sapiens Human PF21122 PF00069 PF21115 6.0 Ki ChEMBL