Molecule Details
| InChIKey | OJSFTALXCYKKFQ-YLJYHZDGSA-N |
|---|---|
| Compound Name | (+)-Femoxetine |
| Canonical SMILES | COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 10 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.66 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB20364 |
|---|---|
| Drug Name | Femoxetine |
| CAS Number | 59859-58-4 |
| Groups | experimental |
| ATC Codes | nan |
| Description | Femoxetine is a small molecule drug. Femoxetine has a monoisotopic molecular weight of 311.19 Da. |
Categories: Anti-Infective Agents Antidepressive Agents Central Nervous System Agents Central Nervous System Depressants Membrane Transport Modulators Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Psychotropic Drugs Selective Serotonin Reuptake Inhibitors Serotonin Agents Serotonin Modulators
Cross-references: BindingDB: 50014247 ChEBI: 135330 CHEMBL94739
Target Activities (10)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P31645 | SLC6A4 | Homo sapiens | Human | PF03491 PF00209 | 8.0 | Ki | BindingDB |
| P11229 | CHRM1 | Homo sapiens | Human | PF00001 | 7.0 | Ki | BindingDB |
| P28335 | HTR2C | Homo sapiens | Human | PF00001 | 6.9 | Ki | BindingDB |
| P08172 | CHRM2 | Homo sapiens | Human | PF00001 | 6.8 | Ki | BindingDB |
| P20309 | CHRM3 | Homo sapiens | Human | PF00001 | 6.7 | Ki | BindingDB |
| P08912 | CHRM5 | Homo sapiens | Human | PF00001 | 6.4 | Ki | BindingDB |
| P08173 | CHRM4 | Homo sapiens | Human | PF00001 | 6.3 | Ki | BindingDB |
| P14416 | DRD2 | Homo sapiens | Human | PF00001 | 6.2 | Ki | BindingDB |
| P35348 | ADRA1A | Homo sapiens | Human | PF00001 | 6.2 | Ki | BindingDB |
| P23975 | SLC6A2 | Homo sapiens | Human | PF00209 | 6.1 | Ki | BindingDB |