Molecule Details
InChIKeyOJGDCBLYJGHCIH-UHFFFAOYSA-N
Compound NameBromhexine
Canonical SMILESCN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL6.74
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB09019
Drug NameBromhexine
CAS Number3572-43-8
Groups approved
ATC Codes R05CB02
DescriptionBromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. It is derived from the Adhatoda vasica plant and aids in the clearance of excess mucus, improving breathing and reducing cough. It was introduced into the market in 1963, and is wide...

Categories: Amines Aniline Compounds Cough and Cold Preparations Cyclohexanes Cyclohexylamines Cycloparaffins Expectorants Respiratory System Agents
Cross-references: BindingDB: 50239965 ChEBI: 77032 CHEMBL253376 ChemSpider: 2348 D07542 PubChem:2442 PubChem:310264976 RxCUI: 1753 Wikipedia: Bromhexine ZINC: ZINC000000608220
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
Q99720 SIGMAR1 Homo sapiens Human PF04622 7.4 IC50 ChEMBL
P10635 CYP2D6 Homo sapiens Human PF00067 6.7 IC50 ChEMBL
O15393 TMPRSS2 Homo sapiens Human PF15494 PF00089 6.1 IC50 BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
Q9BYF1 ACE2 Angiotensin-converting enzyme 2 binder enzymes
Q9BYF1 ACE2 Angiotensin-converting enzyme 2 binder targets
O15393 TMPRSS2 Transmembrane protease serine 2 inhibitor targets