Molecule Details
InChIKeyOJFKUJDRGJSAQB-UHFFFAOYSA-N
Compound NameTak-632
Canonical SMILESN#Cc1c(Oc2ccc(F)c(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)ccc2nc(NC(=O)C3CC3)sc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)17
Pfam Stratification Cross-Family
Avg pChEMBL6.68
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (17)
Target Gene Organism Category Pfam pChEMBL Type Source
P04049 RAF1 Homo sapiens Human PF00130 PF07714 PF02196 8.3 IC50 ChEMBL
P15056 BRAF Homo sapiens Human PF00130 PF07714 PF02196 8.1 IC50 ChEMBL;BindingDB
Q96GD4 AURKB Homo sapiens Human PF00069 7.2 IC50 ChEMBL;BindingDB
Q9Y572 RIPK3 Homo sapiens Human PF00069 PF12721 7.0 Kd ChEMBL;BindingDB
P01127 PDGFB Homo sapiens Human PF00341 PF04692 6.9 IC50 BindingDB
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 6.9 IC50 ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.8 IC50 ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.5 IC50 ChEMBL
Q13546 RIPK1 Homo sapiens Human PF00531 PF07714 6.3 Kd ChEMBL;BindingDB
P49841 GSK3B Homo sapiens Human PF00069 6.3 IC50 ChEMBL
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.2 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.2 IC50 ChEMBL;BindingDB
Q16539 MAPK14 Homo sapiens Human PF00069 6.2 IC50 ChEMBL
P04085 PDGFA Homo sapiens Human PF00341 PF04692 6.2 IC50 ChEMBL;BindingDB
Q02763 TEK Homo sapiens Human PF00041 PF10430 PF07714 6.1 IC50 ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.1 IC50 ChEMBL;BindingDB
P14635 CCNB1 Homo sapiens Human PF02984 PF00134 6.1 IC50 ChEMBL