Molecule Details
InChIKeyOIJXLIIMXHRJJH-KNLIIKEYSA-N
Compound NameDiprenorphine
Canonical SMILESCO[C@]12CC[C@@]3(C[C@@H]1C(C)(C)O)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL9.22
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01548
Drug NameDiprenorphine
CAS Number14357-78-9
Groups illicit investigational vet_approved
ATC Codes nan
DescriptionA narcotic antagonist similar in action to naloxone. It is used to remobilize animals after etorphine neuroleptanalgesia and is considered a specific antagonist to etorphine. [PubChem]

Categories: Alkaloids Central Nervous System Agents Heterocyclic Compounds, Fused-Ring Morphinans Opiate Alkaloids Opioid Antagonists Peripheral Nervous System Agents Phenanthrenes Sensory System Agents
Cross-references: BindingDB: 50001714 ChEBI: 4650 CHEMBL281786 ChemSpider: 391634 Drugs Product Database (DPD): 20253 Guide to Pharmacology: 1617 IUPHAR: 1617 C11794 PubChem:443408 PubChem:46506559 Wikipedia: Diprenorphine ZINC: ZINC000004102215
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P35372 OPRM1 Homo sapiens Human PF00001 9.6 Ki ChEMBL
P41143 OPRD1 Homo sapiens Human PF00001 9.2 IC50 ChEMBL
P41145 OPRK1 Homo sapiens Human PF00001 8.8 Kd ChEMBL;BindingDB
DrugBank Target Actions (4)
Target Gene Target Name Action Type
P35372 OPRM1 Mu-type opioid receptor antagonist targets
P41143 OPRD1 Delta-type opioid receptor antagonist targets
P41145 OPRK1 Kappa-type opioid receptor antagonist targets
O60858 O60858 E3 ubiquitin-protein ligase TRIM13 binder targets