InChIKey	OHRURASPPZQGQM-GCCNXGTGSA-N
Compound Name	Romidepsin
Canonical SMILES	C/C=C1\NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	14
Pfam Stratification	Cross-Family
Avg pChEMBL	7.94
Source	ChEMBL;BindingDB

DrugBank ID	DB06176
Drug Name	Romidepsin
CAS Number	128517-07-7
Groups	approved investigational
ATC Codes	L01XH02
Description	Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy.

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Categories: Amino Acids, Peptides, and Proteins Antibiotics, Antineoplastic Antineoplastic Agents Antineoplastic and Immunomodulating Agents BSEP/ABCB11 Inhibitors Bile Salt Export Pump Inhibitors Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Substrates Depsipeptides Enzyme Inhibitors Highest Risk QTc-Prolonging Agents Histone Deacetylase Inhibitors Histone deacetylase (HDAC) inhibitors Narrow Therapeutic Index Drugs OAT1/SLC22A6 inhibitors OATP1B1/SLCO1B1 Inhibitors OATP1B3 inhibitors OCT2 Inhibitors Organic Anion Transporter 1 Inhibitors Organic Anion Transporting Polypeptide 1B1 Inhibitors Organic Anion Transporting Polypeptide 1B3 Inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Peptides Peptides, Cyclic QTc Prolonging Agents

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Cross-references: BindingDB: 19151 ChEBI: 61080 CHEMBL343448 ChemSpider: 10122002 Drugs Product Database (DPD): 21095 D06637 PharmGKB: PA166161306 PubChem:57515973 PubChem:310264861 RxCUI: 877510 Wikipedia: Romidepsin ZINC: ZINC000003935130