4-[[(3S,4R)-1-(5-cyano-2-pyridinyl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

InChIKey	`OHNNRNYUHNGDNO-LSDHHAIUSA-N`
Compound Name	4-[[(3S,4R)-1-(5-cyano-2-pyridinyl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
Canonical SMILES	`N#Cc1ccc(N2CC[C@@H](Nc3c(C(N)=O)cnc4[nH]ccc34)[C@@H](F)C2)nc1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	15
Pfam Stratification	Cross-Family
Avg pChEMBL	6.87
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P52333	JAK3	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	9.5	IC50	ChEMBL;BindingDB
O60674	JAK2	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	8.5	IC50	ChEMBL;BindingDB
P23458	JAK1	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	8.4	IC50	ChEMBL;BindingDB
P80192	MAP3K9	Homo sapiens	Human	PF07714 PF14604	7.3	IC50	ChEMBL;BindingDB
P17252	PRKCA	Homo sapiens	Human	PF00130 PF00168 PF00069 PF00433	6.9	IC50	ChEMBL;BindingDB
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	6.7	IC50	ChEMBL;BindingDB
Q04759	PRKCQ	Homo sapiens	Human	PF00130 PF21494 PF00069 PF00433	6.5	IC50	ChEMBL;BindingDB
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	6.3	IC50	ChEMBL;BindingDB
P53779	MAPK10	Homo sapiens	Human	PF00069	6.2	IC50	ChEMBL;BindingDB
P20248	CCNA2	Homo sapiens	Human	PF02984 PF00134 PF16500	6.2	IC50	ChEMBL
P24941	CDK2	Homo sapiens	Human	PF00069	6.2	IC50	ChEMBL;BindingDB
P78396	CCNA1	Homo sapiens	Human	PF02984 PF00134 PF16500	6.2	IC50	ChEMBL
O14757	CHEK1	Homo sapiens	Human	PF00069	6.0	IC50	ChEMBL;BindingDB
P49841	GSK3B	Homo sapiens	Human	PF00069	6.0	IC50	ChEMBL;BindingDB
Q9UQM7	CAMK2A	Homo sapiens	Human	PF08332 PF00069	6.0	IC50	ChEMBL;BindingDB