N-(2-pyrazin-2-yl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)naphthalene-1-carboxamide

InChIKey	`OFZGCAMFVYIIHV-UHFFFAOYSA-N`
Compound Name	N-(2-pyrazin-2-yl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)naphthalene-1-carboxamide
Canonical SMILES	`O=C(Nc1c2c(nn1-c1cnccn1)CSC2)c1cccc2ccccc12`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	24
Pfam Stratification	Cross-Family
Avg pChEMBL	6.46
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O00408	PDE2A	Homo sapiens	Human	PF01590 PF00233	6.5	IC50	ChEMBL
O43924	PDE6D	Homo sapiens	Human	PF05351	6.5	IC50	ChEMBL
O60658	PDE8A	Homo sapiens	Human	PF00989 PF08629 PF23198 PF00233	6.5	IC50	ChEMBL
O76074	PDE5A	Homo sapiens	Human	PF01590 PF00233	6.5	IC50	ChEMBL
O76083	PDE9A	Homo sapiens	Human	PF00233	6.5	IC50	ChEMBL
O95263	PDE8B	Homo sapiens	Human	PF13426 PF08629 PF23198 PF00233	6.5	IC50	ChEMBL
P16499	PDE6A	Homo sapiens	Human	PF01590 PF00233	6.5	IC50	ChEMBL
P18545	PDE6G	Homo sapiens	Human	PF04868	6.5	IC50	ChEMBL
P27815	PDE4A	Homo sapiens	Human	PF18100 PF00233	6.5	IC50	ChEMBL
P35913	PDE6B	Homo sapiens	Human	PF01590 PF00233	6.5	IC50	ChEMBL
P51160	PDE6C	Homo sapiens	Human	PF01590 PF00233	6.5	IC50	ChEMBL
P54750	PDE1A	Homo sapiens	Human	PF00233 PF08499	6.5	IC50	ChEMBL
Q01064	PDE1B	Homo sapiens	Human	PF00233 PF08499	6.5	IC50	ChEMBL
Q07343	PDE4B	Homo sapiens	Human	PF18100 PF00233	6.5	IC50	ChEMBL
Q08493	PDE4C	Homo sapiens	Human	PF18100 PF00233	6.5	IC50	ChEMBL
Q08499	PDE4D	Homo sapiens	Human	PF18100 PF00233	6.5	IC50	ChEMBL
Q13370	PDE3B	Homo sapiens	Human	PF00233	6.5	IC50	ChEMBL
Q13946	PDE7A	Homo sapiens	Human	PF00233	6.5	IC50	ChEMBL
Q13956	PDE6H	Homo sapiens	Human	PF04868	6.5	IC50	ChEMBL
Q14123	PDE1C	Homo sapiens	Human	PF00233 PF08499	6.5	IC50	ChEMBL
Q14432	PDE3A	Homo sapiens	Human	PF00233	6.5	IC50	ChEMBL
Q9NP56	PDE7B	Homo sapiens	Human	PF00233	6.5	IC50	ChEMBL
Q9Y233	PDE10A	Homo sapiens	Human	PF01590 PF00233	6.5	IC50	ChEMBL
Q13822	ENPP2	Homo sapiens	Human	PF01223 PF01663 PF01033	6.0	IC50	ChEMBL