Molecule Details
InChIKeyOFIFLUFVENTCNZ-QHCPKHFHSA-N
Compound Name7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
Canonical SMILESCC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3cccc(CN4CCCC4)c3)ncc21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)11
Pfam Stratification Homologous
Avg pChEMBL8.06
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 8.7 IC50 ChEMBL
Q96L34 MARK4 Homo sapiens Human PF02149 PF00069 PF00627 8.7 IC50 ChEMBL
Q9P0L2 MARK1 Homo sapiens Human PF02149 PF00069 PF00627 8.7 IC50 ChEMBL
O60285 NUAK1 Homo sapiens Human PF00069 8.5 IC50 ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 8.5 IC50 ChEMBL
P54646 PRKAA2 Homo sapiens Human PF16579 PF21147 PF00069 8.0 IC50 ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 8.0 IC50 ChEMBL
Q9H0K1 SIK2 Homo sapiens Human PF00069 PF23312 7.9 IC50 ChEMBL
Q9Y2K2 SIK3 Homo sapiens Human PF00069 PF23312 7.4 IC50 ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 7.2 IC50 ChEMBL
P57059 SIK1 Homo sapiens Human PF00069 PF23312 7.0 IC50 ChEMBL