Molecule Details
InChIKeyOFDNQWIFNXBECV-VFSYNPLYSA-N
Compound NameDolastatin 10
Canonical SMILESCC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)15
Pfam Stratification Homologous
Avg pChEMBL8.91
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12730
Drug NameDolastatin 10
CAS Number110417-88-4
Groups investigational
ATC Codes nan
DescriptionDolastatin 10 has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Liver Cancer, and Kidney Cancer, among others.

Categories: Amino Acids, Peptides, and Proteins Antimitotic Agents Antineoplastic Agents Mitosis Modulators Peptides Peptides, Cyclic Tubulin Modulators
Cross-references: BindingDB: 50216333 ChEBI: 67357 CHEMBL39541 ChemSpider: 7986684 PDB: SR6 PubChem:9810929 PubChem:347828924 ZINC: ZINC000095803508
Target Activities (15)
Target Gene Organism Category Pfam pChEMBL Type Source
P04350 TUBB4A Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
P07437 TUBB Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
P0DPH7 TUBA3C Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
P68363 TUBA1B Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
P68366 TUBA4A Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
P68371 TUBB4B Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
Q13509 TUBB3 Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
Q13885 TUBB2A Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
Q3ZCM7 TUBB8 Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
Q6PEY2 TUBA3E Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
Q71U36 TUBA1A Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
Q9BQE3 TUBA1C Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
Q9BUF5 TUBB6 Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
Q9BVA1 TUBB2B Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
Q9H4B7 TUBB1 Homo sapiens Human PF00091 PF03953 8.9 IC50 ChEMBL
DrugBank Target Actions (1)
Target Gene Target Name Action Type
Q13885 TUBB2A Tubulin beta-2A chain inhibitor targets