InChIKey	OEKWJQXRCDYSHL-FNOIDJSQSA-N
Canonical SMILES	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)c2n1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Cross-Family
Avg pChEMBL	7.07
Source	ChEMBL;BindingDB

DrugBank ID	DB08816
Drug Name	Ticagrelor
CAS Number	274693-27-5
Groups	approved investigational
ATC Codes	B01AC24
Description	Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] ...

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Categories: Anticoagulants Antiplatelet agents Blood and Blood Forming Organs Carbohydrates Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (weak) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers (weak) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (weak) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Decreased Platelet Aggregation Glycosides Hematologic Agents Heterocyclic Compounds, Fused-Ring Nucleic Acids, Nucleotides, and Nucleosides Nucleosides P-glycoprotein inhibitors P-glycoprotein substrates P2Y12 Platelet Inhibitor Phenylalanine Hydroxylase Activators Platelet Aggregation Inhibitors Excl. Heparin Purine Nucleosides Purinergic Agents Purinergic Antagonists Purinergic P2 Receptor Antagonists Purinergic P2Y Receptor Antagonists Purines Ribonucleosides

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Cross-references: BindingDB: 50397205 ChEBI: 68558 CHEMBL398435 ChemSpider: 8047109 Drugs Product Database (DPD): 20742 D09017 PDB: TIQ PharmGKB: PA165374673 PubChem:9871419 PubChem:175427101 RxCUI: 1116632 Wikipedia: Ticagrelor ZINC: ZINC000028957444