N-(2-hydroxy-1-phenylethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydro-2H-pyridine-1-carboxamide

InChIKey	`OEEGUWWPGAZRIJ-UHFFFAOYSA-N`
Compound Name	N-(2-hydroxy-1-phenylethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydro-2H-pyridine-1-carboxamide
Canonical SMILES	`O=C(NC(CO)c1ccccc1)N1CC=C(c2c[nH]c3ncccc23)CC1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	21
Pfam Stratification	Cross-Family
Avg pChEMBL	6.53
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O75116	ROCK2	Homo sapiens	Human	PF25346 PF00069 PF08912	7.4	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	7.2	Ki	ChEMBL
Q13976	PRKG1	Homo sapiens	Human	PF00027 PF16808 PF00069	7.0	Ki	ChEMBL
P17612	PRKACA	Homo sapiens	Human	PF00069	6.9	Ki	ChEMBL
O95819	MAP4K4	Homo sapiens	Human	PF00780 PF00069	6.8	Ki	ChEMBL
Q13131	PRKAA1	Homo sapiens	Human	PF16579 PF21147 PF00069	6.7	Ki	ChEMBL
O75582	RPS6KA5	Homo sapiens	Human	PF00069 PF00433	6.6	Ki	ChEMBL
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	6.6	Ki	ChEMBL
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	6.6	Ki	ChEMBL
Q16513	PKN2	Homo sapiens	Human	PF02185 PF00069 PF00433	6.6	Ki	ChEMBL
P23443	RPS6KB1	Homo sapiens	Human	PF00069 PF00433	6.5	Ki	ChEMBL
Q12851	MAP4K2	Homo sapiens	Human	PF00780 PF00069	6.4	Ki	ChEMBL
Q13237	PRKG2	Homo sapiens	Human	PF00027 PF00069	6.4	Ki	ChEMBL
Q8N4C8	MINK1	Homo sapiens	Human	PF00780 PF00069	6.4	Ki	ChEMBL
Q9HBY8	SGK2	Homo sapiens	Human	PF00069 PF00433	6.4	Ki	ChEMBL
P28482	MAPK1	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
Q13627	DYRK1A	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	6.1	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
Q9BXA7	TSSK1B	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
Q9UEE5	STK17A	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL