Molecule Details
| InChIKey | ODMXWZROLKITMS-RISCZKNCSA-N |
|---|---|
| Compound Name | Pf-06459988 |
| Canonical SMILES | C=CC(=O)N1C[C@H](COc2nc(Nc3cnn(C)c3)nc3[nH]cc(Cl)c23)[C@@H](OC)C1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.78 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB14768 |
|---|---|
| Drug Name | PF-06459988 |
| CAS Number | 1428774-45-1 |
| Groups | investigational |
| ATC Codes | nan |
| Description | PF-06459988 is under investigation in clinical trial NCT02297425 (A Study For Patients With EGFRm (Epidermal Growth Factor Receptor Mutant) Lung Cancer). |
Cross-references: BindingDB: 50159360 CHEMBL3786098 ChemSpider: 49070958 ZINC: ZINC000204947687
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P00533 | EGFR | Homo sapiens | Human | PF00757 PF14843 PF07714 PF01030 PF21314 | 7.9 | IC50 | ChEMBL;BindingDB |
| P04626 | ERBB2 | Homo sapiens | Human | PF00757 PF14843 PF07714 PF01030 PF21314 | 7.8 | IC50 | BindingDB |
| P21860 | ERBB3 | Homo sapiens | Human | PF00757 PF14843 PF07714 PF01030 | 7.7 | IC50 | ChEMBL;BindingDB |