Molecule Details
InChIKeyOCAPBUJLXMYKEJ-UHFFFAOYSA-N
Compound NameBifonazole
Canonical SMILESc1ccc(-c2ccc(C(c3ccccc3)n3ccnc3)cc2)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL6.42
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB04794
Drug NameBifonazole
CAS Number60628-96-8
Groups approved
ATC Codes D01AC10 D01AC60
DescriptionBifonazole is an azole antifungal drug.

Categories: Anti-Infective Agents Antifungal Agents Antifungals for Dermatological Use Antifungals for Topical Use Azole Antifungals Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 Enzyme Inhibitors Dermatologicals Imidazole and Triazole Derivatives
Cross-references: BindingDB: 50128548 ChEBI: 78692 CHEMBL277535 ChemSpider: 2287 PDB: TMI PharmGKB: PA164746464 PubChem:2378 PubChem:46507284 RxCUI: 19295 Therapeutic Targets Database: DAP000877 Wikipedia: Bifonazole
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P05093 CYP17A1 Homo sapiens Human PF00067 6.7 IC50 ChEMBL
Q16850 CYP51A1 Homo sapiens Human PF00067 6.5 IC50 ChEMBL
P08684 CYP3A4 Homo sapiens Human PF00067 6.1 IC50 ChEMBL
DrugBank Target Actions (5)
Target Gene Target Name Action Type
P05181 CYP2E1 Cytochrome P450 2E1 inhibitor enzymes
P08684 CYP3A4 Cytochrome P450 3A4 inhibitor enzymes
P11511 CYP19A1 Aromatase inhibitor enzymes
P20813 CYP2B6 Cytochrome P450 2B6 binder targets
P10613 ERG11 Lanosterol 14-alpha demethylase inhibitor targets