InChIKey	OBMNJSNZOWALQB-NCQNOWPTSA-N
Compound Name	Grazoprevir
Canonical SMILES	C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)O[C@@H]1C[C@H]1CCCCCc1nc3ccc(OC)cc3nc1O2)C(=O)NS(=O)(=O)C1CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	9.39
Source	ChEMBL;BindingDB

DrugBank ID	DB11575
Drug Name	Grazoprevir
CAS Number	1350514-68-9
Groups	approved
ATC Codes	J05AP11 J05AP54
Description	Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 bei...

---

Categories: Acids, Acyclic Amides Anti-Infective Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Antivirals for treatment of HCV infections BCRP/ABCG2 Inhibitors Cycloparaffins Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals HCV NS3/4A Protease Inhibitors Heterocyclic Compounds, Fused-Ring Lactams NS3/4A Protease Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 substrates P-glycoprotein substrates Sulfones Sulfur Compounds Treatments for Hepatitis C

---

Cross-references: BindingDB: 50485492 ChEBI: 132975 CHEMBL2063090 ChemSpider: 28506694 Drugs Product Database (DPD): 22679 D10639 PDB: SUE PharmGKB: PA166163437 PubChem:44603531 PubChem:347827989 RxCUI: 1734630 Wikipedia: Grazoprevir ZINC: ZINC000095551509