Molecule Details
InChIKeyOARXLGLBMAHALM-NRFANRHFSA-N
Compound Name6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}isoquinolin-3-amine
Canonical SMILESNc1cc2cc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)ccc2cn1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)12
Pfam Stratification Cross-Family
Avg pChEMBL7.31
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (12)
Target Gene Organism Category Pfam pChEMBL Type Source
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 8.5 IC50 ChEMBL;BindingDB
P17612 PRKACA Homo sapiens Human PF00069 8.1 IC50 ChEMBL
P22612 PRKACG Homo sapiens Human PF00069 8.1 IC50 ChEMBL
P22694 PRKACB Homo sapiens Human PF00069 8.1 IC50 ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 7.7 IC50 ChEMBL;BindingDB
P06493 CDK1 Homo sapiens Human PF00069 7.7 IC50 ChEMBL
P05129 PRKCG Homo sapiens Human PF00130 PF00168 PF00069 PF00433 7.5 IC50 ChEMBL;BindingDB
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 7.1 IC50 ChEMBL;BindingDB
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.3 IC50 ChEMBL
P19784 CSNK2A2 Homo sapiens Human PF00069 6.2 IC50 ChEMBL
P67870 CSNK2B Homo sapiens Human PF01214 6.2 IC50 ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.2 IC50 ChEMBL