Molecule Details
| InChIKey | NZNTWOVDIXCHHS-LSDHHAIUSA-N |
|---|---|
| Compound Name | Prt-060318 |
| Canonical SMILES | Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.82 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB08361 |
|---|---|
| Drug Name | 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide |
| CAS Number | nan |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Cross-references: BindingDB: 50396073 CHEMBL1235110 ChemSpider: 9668647 PDB: P5C PubChem:11493841 PubChem:99444832 ZINC: ZINC000003941369
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P43405 | SYK | Homo sapiens | Human | PF07714 PF00017 | 8.3 | IC50 | ChEMBL;BindingDB |
| P27361 | MAPK3 | Homo sapiens | Human | PF00069 | 7.8 | IC50 | ChEMBL |
| P28482 | MAPK1 | Homo sapiens | Human | PF00069 | 7.8 | IC50 | ChEMBL;BindingDB |
| Q9HCN6 | GP6 | Homo sapiens | Human | PF13895 PF13927 | 7.3 | IC50 | ChEMBL;BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P43405 | SYK | Tyrosine-protein kinase SYK | inhibitor | targets |