Molecule Details
InChIKeyNYMGNSNKLVNMIA-UHFFFAOYSA-N
Canonical SMILESCC(C)NNC(=O)c1ccncc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL6.04
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB04818
Drug NameIproniazid
CAS Number54-92-2
Groups approved withdrawn
ATC Codes N06AF05
DescriptionWithdrawn from the Canadian market in July 1964 due to interactions with food products containing tyrosine.

Categories: Agents that produce hypertension Agents that reduce seizure threshold Antidepressive Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Hydrazines Isonicotinic Acids Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Monoamine Oxidase Inhibitors Monoamine Oxidase Inhibitors, Non-Selective Nervous System Psychoanaleptics Psychotropic Drugs Pyridines Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 29136 ChEBI: 5958 CHEMBL92401 ChemSpider: 3617 C11777 D02579 PubChem:3748 PubChem:46505059 RxCUI: 5981 Wikipedia: Iproniazid ZINC: ZINC000000001579
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P21397 MAOA Homo sapiens Human PF01593 6.1 IC50 ChEMBL;BindingDB
P27338 MAOB Homo sapiens Human PF01593 6.0 IC50 ChEMBL;BindingDB
DrugBank Target Actions (6)
Target Gene Target Name Action Type
P10635 CYP2D6 Cytochrome P450 2D6 inhibitor enzymes
P11712 CYP2C9 Cytochrome P450 2C9 inhibitor enzymes
P21397 MAOA Amine oxidase [flavin-containing] A inhibitor enzymes
P27338 MAOB Amine oxidase [flavin-containing] B inhibitor enzymes
P21397 MAOA Amine oxidase [flavin-containing] A inhibitor targets
P27338 MAOB Amine oxidase [flavin-containing] B inhibitor targets