Molecule Details
| InChIKey | NYMGNSNKLVNMIA-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | CC(C)NNC(=O)c1ccncc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.04 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB04818 |
|---|---|
| Drug Name | Iproniazid |
| CAS Number | 54-92-2 |
| Groups | approved withdrawn |
| ATC Codes | N06AF05 |
| Description | Withdrawn from the Canadian market in July 1964 due to interactions with food products containing tyrosine. |
Categories: Agents that produce hypertension Agents that reduce seizure threshold Antidepressive Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Hydrazines Isonicotinic Acids Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Monoamine Oxidase Inhibitors Monoamine Oxidase Inhibitors, Non-Selective Nervous System Psychoanaleptics Psychotropic Drugs Pyridines Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 29136 ChEBI: 5958 CHEMBL92401 ChemSpider: 3617 C11777 D02579 PubChem:3748 PubChem:46505059 RxCUI: 5981 Wikipedia: Iproniazid ZINC: ZINC000000001579
Target Activities (2)
DrugBank Target Actions (6)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P10635 | CYP2D6 | Cytochrome P450 2D6 | inhibitor | enzymes |
| P11712 | CYP2C9 | Cytochrome P450 2C9 | inhibitor | enzymes |
| P21397 | MAOA | Amine oxidase [flavin-containing] A | inhibitor | enzymes |
| P27338 | MAOB | Amine oxidase [flavin-containing] B | inhibitor | enzymes |
| P21397 | MAOA | Amine oxidase [flavin-containing] A | inhibitor | targets |
| P27338 | MAOB | Amine oxidase [flavin-containing] B | inhibitor | targets |