Molecule Details
InChIKeyNWAUBAGBGOPJLF-UHFFFAOYSA-N
Compound NameThienopyrimidine deriv. 26
Canonical SMILESCc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)51
Pfam Stratification Cross-Family
Avg pChEMBL6.92
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (51)
Target Gene Organism Category Pfam pChEMBL Type Source
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 8.4 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 8.4 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 8.2 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 8.2 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 8.0 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.9 IC50 ChEMBL;BindingDB
Q02763 TEK Homo sapiens Human PF00041 PF10430 PF07714 7.9 pIC50 TTD_MultiTarget
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.9 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 7.9 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.8 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 7.7 IC50 ChEMBL;BindingDB
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 7.7 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.6 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 7.6 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.6 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.3 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.2 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 7.1 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 7.1 Ki ChEMBL
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 7.1 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.8 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.8 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.8 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.7 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.7 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.7 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.7 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.5 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.4 Ki ChEMBL
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.4 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.4 Ki ChEMBL
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 6.3 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.3 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.3 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.3 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.2 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.2 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.2 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.1 Ki ChEMBL
P51957 NEK4 Homo sapiens Human PF00069 6.1 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.0 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.0 Ki ChEMBL