Molecule Details
InChIKeyNVKAWKQGWWIWPM-ABEVXSGRSA-N
Compound NameDihydrotestosterone
Canonical SMILESC[C@]12CCC(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)5
Pfam Stratification Cross-Family
Avg pChEMBL7.43
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB02901
Drug NameStanolone
CAS Number521-18-6
Groups illicit investigational
ATC Codes A14AA01 G03BB02
DescriptionA potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid.

Categories: 5-Androstanon (3) Derivatives Alimentary Tract and Metabolism Anabolic Agents for Systemic Use Anabolic Steroids Androgens Androstan Derivatives Androstanes Androstanols Fused-Ring Compounds Genito Urinary System and Sex Hormones Gonadal Hormones Gonadal Steroid Hormones Hormones Hormones, Hormone Substitutes, and Hormone Antagonists P-glycoprotein substrates Sex Hormones and Modulators of the Genital System Steroids Testosterone Congeners Testosterone and derivatives Thyroxine-binding globulin inhibitors
Cross-references: BindingDB: 50366473 ChEBI: 16330 CHEMBL27769 ChemSpider: 10189 C03917 D07456 PDB: DHT PubChem:10635 PubChem:46506828 RxCUI: 236781 Wikipedia: Dihydrotestosterone ZINC: ZINC000003814360
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
P04278 SHBG Homo sapiens Human PF00054 9.1 IC50 ChEMBL;BindingDB
P10275 AR Homo sapiens Human PF02166 PF00104 PF00105 8.7 Ki ChEMBL;BindingDB
P11511 CYP19A1 Homo sapiens Human PF00067 6.7 Ki ChEMBL;BindingDB
P08235 NR3C2 Homo sapiens Human PF00104 PF00105 6.4 IC50 ChEMBL;BindingDB
P04150 NR3C1 Homo sapiens Human PF02155 PF00104 PF00105 6.3 IC50 ChEMBL;BindingDB
DrugBank Target Actions (10)
Target Gene Target Name Action Type
P04278 SHBG Sex hormone-binding globulin binder carriers
P42330 AKR1C3 Aldo-keto reductase family 1 member C3 product of enzymes
P05093 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase substrate enzymes
P05108 P05108 Cholesterol side-chain cleavage enzyme, mitochondrial substrate enzymes
P11511 CYP19A1 Aromatase substrate enzymes
P10275 AR Androgen receptor agonist targets
P03372 ESR1 Estrogen receptor binder targets
P08235 NR3C2 Mineralocorticoid receptor binder targets
P14061 HSD17B1 17-beta-hydroxysteroid dehydrogenase type 1 binder targets
P08183 ABCB1 ATP-dependent translocase ABCB1 substrate transporters