Molecule Details
InChIKeyNTXWXFSAJRMWNA-JTQLQIEISA-N
Compound Name2-chloro-5-(6-methoxy-1H-benzimidazol-2-yl)-4-[[(3S)-piperidin-3-yl]amino]-7H-thieno[2,3-b]pyridin-6-one
Canonical SMILESCOc1ccc2[nH]c(-c3c(N[C@H]4CCCNC4)c4cc(Cl)sc4[nH]c3=O)nc2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)15
Pfam Stratification Cross-Family
Avg pChEMBL6.77
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (15)
Target Gene Organism Category Pfam pChEMBL Type Source
O14757 CHEK1 Homo sapiens Human PF00069 8.6 IC50 ChEMBL;BindingDB
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.7 IC50 ChEMBL
P05129 PRKCG Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
P05771 PRKCB Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
P17252 PRKCA Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
P24723 PRKCH Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
P41743 PRKCI Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.7 IC50 ChEMBL
Q02156 PRKCE Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.7 IC50 ChEMBL
Q04759 PRKCQ Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.7 IC50 ChEMBL
Q05513 PRKCZ Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.7 IC50 ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.7 IC50 ChEMBL
Q15139 PRKD1 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.7 IC50 ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.5 IC50 ChEMBL;BindingDB
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.4 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.4 IC50 ChEMBL