Molecule Details
| InChIKey | NTJQREUGJKIARY-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2,5-Dimethoxy-4-Methylamphetamine |
| Canonical SMILES | COc1cc(CC(C)N)c(OC)cc1C |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 7 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.68 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01528 |
|---|---|
| Drug Name | 4-Methyl-2,5-dimethoxyamphetamine |
| CAS Number | 15588-95-1 |
| Groups | experimental illicit |
| ATC Codes | nan |
| Description | A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD. |
Cross-references: BindingDB: 50005265 CHEMBL8600 ChemSpider: 77462 Guide to Pharmacology: 164 IUPHAR: 164 PubChem:85875 PubChem:46504804
Target Activities (7)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P41595 | HTR2B | Homo sapiens | Human | PF00001 | 7.9 | Ki | BindingDB |
| P07550 | ADRB2 | Homo sapiens | Human | PF00001 | 7.3 | Ki | BindingDB |
| P28221 | HTR1D | Homo sapiens | Human | PF00001 | 6.7 | Ki | BindingDB |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 6.5 | Ki | BindingDB |
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 6.2 | Ki | BindingDB |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 6.1 | Ki | BindingDB |
| P18825 | ADRA2C | Homo sapiens | Human | PF00001 | 6.0 | Ki | BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P28223 | HTR2A | 5-hydroxytryptamine receptor 2A | inhibitor | targets |