N-[5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-3-(4-methylpiperazin-1-yl)propanamide

InChIKey	`NSKYYUZMAXEZIR-AQTBWJFISA-N`
Compound Name	N-[5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-3-(4-methylpiperazin-1-yl)propanamide
Canonical SMILES	`Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)CCN1CCN(C)CC1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	15
Pfam Stratification	Cross-Family
Avg pChEMBL	6.96
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	8.4	Ki	ChEMBL;BindingDB
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	7.7	Ki	ChEMBL;BindingDB
P09619	PDGFRB	Homo sapiens	Human	PF00047 PF13927 PF25305 PF07714	7.7	Ki	ChEMBL;BindingDB
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	7.2	Ki	ChEMBL;BindingDB
P22607	FGFR3	Homo sapiens	Human	PF21165 PF07679 PF13927 PF07714	7.0	Ki	ChEMBL;BindingDB
Q9UM73	ALK	Homo sapiens	Human	PF12810 PF00629 PF07714	7.0	Ki	ChEMBL;BindingDB
O14757	CHEK1	Homo sapiens	Human	PF00069	7.0	Ki	ChEMBL;BindingDB
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.9	Ki	ChEMBL;BindingDB
P42684	ABL2	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.7	Ki	ChEMBL;BindingDB
P10721	KIT	Homo sapiens	Human	PF00047 PF07714	6.7	Ki	ChEMBL;BindingDB
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	6.6	Ki	ChEMBL;BindingDB
Q14289	PTK2B	Homo sapiens	Human	PF21477 PF00373 PF18038 PF03623 PF07714	6.5	Ki	ChEMBL;BindingDB
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	6.5	Ki	ChEMBL;BindingDB
Q05397	PTK2	Homo sapiens	Human	PF21477 PF00373 PF18038 PF03623 PF07714	6.3	Ki	ChEMBL;BindingDB
P15735	PHKG2	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL;BindingDB