Molecule Details
InChIKeyNSDIHUXUFJHXRA-UHFFFAOYSA-N
Compound Name1-(8-Fluoroquinolin-4-yl)-3-pyrazin-2-ylurea
Canonical SMILESO=C(Nc1cnccn1)Nc1ccnc2c(F)cccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)11
Pfam Stratification Cross-Family
Avg pChEMBL6.75
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
P49840 GSK3A Homo sapiens Human PF00069 8.3 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 8.3 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.5 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.4 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.3 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.1 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.0 Ki ChEMBL