Molecule Details
InChIKeyNRPQELCNMADTOZ-OAQYLSRUSA-N
Compound NameLecozotan
Canonical SMILESC[C@H](CN(C(=O)c1ccc(C#N)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL7.16
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12540
Drug NameLecozotan
CAS Number434283-16-6
Groups investigational
ATC Codes nan
DescriptionLecozotan has been used in trials studying the treatment of Alzheimer Disease.

Categories: Antidepressive Agents Central Nervous System Depressants Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1A Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists
Cross-references: BindingDB: 50166903 CHEMBL372205 ChemSpider: 8292400 PubChem:10116877 PubChem:347828766 Wikipedia: Lecozotan
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P08908 HTR1A Homo sapiens Human PF00001 8.0 IC50 ChEMBL;BindingDB
P21917 DRD4 Homo sapiens Human PF00001 7.0 Ki BindingDB
P35462 DRD3 Homo sapiens Human PF00001 6.5 Ki BindingDB
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P08908 HTR1A 5-hydroxytryptamine receptor 1A antagonist targets
P08908 HTR1A 5-hydroxytryptamine receptor 1 regulator targets