Molecule Details
| InChIKey | NROLQUCDBSGNQD-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-[4-[[5-Chloro-4-[(2,5-difluorophenyl)methylamino]pyrimidin-2-yl]amino]pyrazol-1-yl]ethanol |
| Canonical SMILES | OCCn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.87 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O60674 | JAK2 | Homo sapiens | Human | PF18379 PF18377 PF17887 PF07714 PF21990 | 9.5 | IC50 | ChEMBL;BindingDB |
| P52333 | JAK3 | Homo sapiens | Human | PF18379 PF18377 PF17887 PF07714 PF21990 | 9.0 | IC50 | ChEMBL;BindingDB |
| P23458 | JAK1 | Homo sapiens | Human | PF18379 PF18377 PF17887 PF07714 PF21990 | 8.1 | IC50 | ChEMBL;BindingDB |