InChIKey	NQDJXKOVJZTUJA-UHFFFAOYSA-N
Compound Name	Nevirapine
Canonical SMILES	Cc1ccnc2c1NC(=O)c1cccnc1N2C1CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	6.83
Source	BindingDB;ChEMBL

DrugBank ID	DB00238
Drug Name	Nevirapine
CAS Number	129618-40-2
Groups	approved investigational
ATC Codes	J05AG01 J05AR05 J05AR07
Description	A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.

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Categories: Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Antivirals used in combination for the treatment of HIV infections Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (weak) Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strong) Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Enzyme Inhibitors Hepatotoxic Agents Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor Inducers of Drug Clearance Non-Nucleoside Reverse Transcriptase Inhibitors Nonnucleoside Reverse Transcriptase Inhibitors Nucleic Acid Synthesis Inhibitors OCT1 inhibitors Pyridines Reverse Transcriptase Inhibitors

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Cross-references: BindingDB: 1434 ChEBI: 63613 CHEMBL57 ChemSpider: 4308 Drugs Product Database (DPD): 11796 C07263 D00435 PDB: NVP PharmGKB: PA450616 PubChem:4463 PubChem:46506789 RxCUI: 53654 Therapeutic Targets Database: DAP000184 Wikipedia: Nevirapine ZINC: ZINC000000004778