Molecule Details
| InChIKey | NPUKDXXFDDZOKR-LLVKDONJSA-N |
|---|---|
| Canonical SMILES | CCOC(=O)c1cncn1[C@H](C)c1ccccc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 9.34 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00292 |
|---|---|
| Drug Name | Etomidate |
| CAS Number | 33125-97-2 |
| Groups | approved investigational |
| ATC Codes | N01AX07 |
| Description | Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic. |
Categories: Adrenergic Agonists Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Agents producing tachycardia Agents that produce hypertension Anesthetics Anesthetics, General Anesthetics, Intravenous Central Nervous System Agents Central Nervous System Depressants Drugs that are Mainly Renally Excreted Hypnotics and Sedatives Imidazoles Nervous System
Cross-references: BindingDB: 50125935 ChEBI: 4910 CHEMBL681 ChemSpider: 580864 Drugs Product Database (DPD): 23454 C07522 D00548 PDB: V8D PharmGKB: PA164743987 PubChem:667484 PubChem:46507012 RxCUI: 4177 Therapeutic Targets Database: DAP000669 Wikipedia: Etomidate ZINC: ZINC000000001408
Target Activities (2)
DrugBank Target Actions (7)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P11166 | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1 | inhibitor | carriers |
| P15538 | CYP11B1 | Cytochrome P450 11B1, mitochondrial | inhibitor | enzymes |
| P19099 | CYP11B2 | Cytochrome P450 11B2, mitochondrial | inhibitor | enzymes |
| P14867 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | agonist | targets |
| P18089 | ADRA2B | Alpha-2B adrenergic receptor | agonist | targets |
| Q99928 | GABRG3 | Gamma-aminobutyric acid receptor subunit gamma-3 | modulator | targets |
| P14867 | GABRA1 | GABA(A) Receptor | positive allosteric modulator | targets |