Molecule Details
InChIKeyNPFDWHQSDBWQLH-QZTJIDSGSA-N
Compound NameFilorexant
Canonical SMILESCc1ccc(-c2ncccn2)c(C(=O)N2C[C@H](COc3ccc(F)cn3)CC[C@H]2C)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL9.06
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12158
Drug NameFilorexant
CAS Number1088991-73-4
Groups investigational
ATC Codes nan
DescriptionFilorexant has been used in trials studying the prevention and treatment of Migraine, Headache, Polysomnography, Diabetic Neuropathy, Painful, and Major Depressive Disorder, Recurrent.

Cross-references: BindingDB: 104692 CHEMBL2107822 ChemSpider: 28528372 PDB: NT5 PubChem:25128145 PubChem:347828451 Wikipedia: Filorexant ZINC: ZINC000043201232
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
O43614 HCRTR2 Homo sapiens Human PF00001 PF03827 9.5 Ki ChEMBL;BindingDB
O43613 HCRTR1 Homo sapiens Human PF00001 8.6 Ki ChEMBL;BindingDB