InChIKey	NNACHAUCXXVJSP-UHFFFAOYSA-N
Compound Name	Pitolisant
Canonical SMILES	Clc1ccc(CCCOCCCN2CCCCC2)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Cross-Family
Avg pChEMBL	7.95
Source	ChEMBL;BindingDB

DrugBank ID	DB11642
Drug Name	Pitolisant
CAS Number	362665-56-3
Groups	approved investigational
ATC Codes	N07XX11
Description	Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy.[L8063] Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations,...

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Categories: Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inducers (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs causing inadvertant photosensitivity Drugs that are Mainly Renally Excreted Histamine Antagonists Histamine H3 Antagonists Histamine-3 (H3) Receptor Antagonists/Inverse Agonists Histamine-3 Receptor Antagonist/Inverse Agonist Moderate Risk QTc-Prolonging Agents Nervous System OCT1 inhibitors Photosensitizing Agents QTc Prolonging Agents Receptors, Histamine H3

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Cross-references: BindingDB: 50247053 ChEBI: 134709 CHEMBL462605 ChemSpider: 8123714 Drugs Product Database (DPD): 23594 RxCUI: 2197878 Wikipedia: Pitolisant ZINC: ZINC000034045468