Molecule Details
InChIKeyNMJMRSQTDLRCRQ-UHFFFAOYSA-N
Compound Name1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
Canonical SMILESCOc1cc(N2CCC(O)CC2)ccc1Nc1cc(Nc2ccccc2S(=O)(=O)C(C)C)c2cc[nH]c2n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Cross-Family
Avg pChEMBL6.79
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 7.7 IC50 ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 7.5 IC50 ChEMBL
P33981 TTK Homo sapiens Human PF00069 6.9 IC50 ChEMBL;BindingDB
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.5 IC50 ChEMBL
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.4 IC50 ChEMBL
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 6.3 IC50 ChEMBL
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 6.1 IC50 ChEMBL