4-methyl-8-propan-2-yl-10H-benzo[b][1,8]naphthyridin-5-one

InChIKey	`NMHMCXTYPRADBA-UHFFFAOYSA-N`
Compound Name	4-methyl-8-propan-2-yl-10H-benzo[b][1,8]naphthyridin-5-one
Canonical SMILES	`Cc1ccnc2[nH]c3cc(C(C)C)ccc3c(=O)c12`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	20
Pfam Stratification	Cross-Family
Avg pChEMBL	6.43
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.9	Ki	ChEMBL
Q00535	CDK5	Homo sapiens	Human	PF00069	6.9	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	6.9	Ki	ChEMBL
P50750	CDK9	Homo sapiens	Human	PF00069	6.8	Ki	ChEMBL
Q04771	ACVR1	Homo sapiens	Human	PF01064 PF07714 PF08515	6.8	Ki	ChEMBL
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.6	Ki	ChEMBL
P45983	MAPK8	Homo sapiens	Human	PF00069	6.6	Ki	ChEMBL
P49840	GSK3A	Homo sapiens	Human	PF00069	6.6	Ki	ChEMBL
P49841	GSK3B	Homo sapiens	Human	PF00069	6.6	Ki	ChEMBL
P50613	CDK7	Homo sapiens	Human	PF00069	6.6	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
Q13627	DYRK1A	Homo sapiens	Human	PF00069	6.3	Ki	ChEMBL
O60674	JAK2	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	6.2	Ki	ChEMBL
Q9Y463	DYRK1B	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.1	Ki	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	6.1	Ki	ChEMBL
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	6.0	Ki	ChEMBL
Q05397	PTK2	Homo sapiens	Human	PF21477 PF00373 PF18038 PF03623 PF07714	6.0	Ki	ChEMBL
Q16620	NTRK2	Homo sapiens	Human	PF07679 PF13855 PF16920 PF01462 PF07714	6.0	Ki	ChEMBL
Q5S007	LRRK2	Homo sapiens	Human	PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477	6.0	Ki	ChEMBL