Molecule Details
InChIKeyNMFKDDRQSNVETB-UHFFFAOYSA-N
Compound NameCdk4 Inhibitor
Canonical SMILESO=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1[nH]c3cc(Br)ccc3c21
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.7
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
P11802 CDK4 Homo sapiens Human PF00069 7.1 IC50 ChEMBL;BindingDB
P24385 CCND1 Homo sapiens Human PF02984 PF00134 7.1 IC50 ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.8 IC50 ChEMBL
Q15078 CDK5R1 Homo sapiens Human PF03261 6.8 IC50 ChEMBL;BindingDB
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.7 IC50 ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.7 pIC50 TTD_MultiTarget
P24941 CDK2 Homo sapiens Human PF00069 6.5 IC50 ChEMBL;BindingDB
O96020 CCNE2 Homo sapiens Human PF02984 PF00134 6.3 IC50 ChEMBL
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 6.3 IC50 ChEMBL