Molecule Details
InChIKeyNLUPJKQOKWBWFC-UHFFFAOYSA-N
Compound Name3-Ethyl-5-[2-(3-methoxyanilino)pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-one
Canonical SMILESCCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)69
Pfam Stratification Cross-Family
Avg pChEMBL6.7
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (69)
Target Gene Organism Category Pfam pChEMBL Type Source
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 8.4 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 8.3 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.9 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 7.9 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 7.9 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.7 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.7 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 7.7 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 7.7 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 7.6 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.4 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.4 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.4 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.4 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.3 Ki ChEMBL
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 7.2 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.1 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 7.1 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 7.1 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.9 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.9 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.8 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.8 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.8 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.7 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.7 Ki ChEMBL
O15111 CHUK Homo sapiens Human PF18397 PF12179 PF00069 6.6 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.6 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.6 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.5 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.5 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.5 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 6.5 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.5 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.4 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 6.4 Ki ChEMBL
P51957 NEK4 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.4 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 Ki ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.3 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.3 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q8TDC3 BRSK1 Homo sapiens Human PF21122 PF00069 PF21115 6.3 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.3 Ki ChEMBL
O15264 MAPK13 Homo sapiens Human PF00069 6.2 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.2 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.2 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.2 Ki ChEMBL
Q96KB5 PBK Homo sapiens Human PF00069 6.2 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.1 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.1 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.1 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.1 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 6.1 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.0 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.0 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.0 Ki ChEMBL
Q9Y6M4 CSNK1G3 Homo sapiens Human PF12605 PF00069 6.0 Ki ChEMBL