Molecule Details
| InChIKey | NHXLMOGPVYXJNR-ATOGVRKGSA-N |
|---|---|
| Compound Name | Somatostatin |
| Canonical SMILES | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 9.36 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB09099 |
|---|---|
| Drug Name | Somatostatin |
| CAS Number | 38916-34-6 |
| Groups | approved investigational withdrawn |
| ATC Codes | H01CB01 |
| Description | Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues [T28] that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and glucagon, and is also generated in the ... |
Categories: Amino Acids, Peptides, and Proteins Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 Enzyme Inhibitors Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hypothalamic Hormones Nerve Tissue Proteins Neuropeptides P-glycoprotein substrates Pancreatic Hormones Peptide Hormones Peptides Pituitary Hormone Release Inhibiting Hormones Pituitary and Hypothalamic Hormones and Analogues Proteins Somatostatin and Analogues Somatostatin, agonists Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins
Cross-references: BindingDB: 81767 ChEBI: 64628 CHEMBL1823872 ChemSpider: 17286507 Drugs Product Database (DPD): 11700 D07431 PubChem:16129681 PubChem:310265025 RxCUI: 9939 Wikipedia: Somatostatin
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P30874 | SSTR2 | Homo sapiens | Human | PF00001 | 10.1 | Ki | ChEMBL;BindingDB |
| P35346 | SSTR5 | Homo sapiens | Human | PF00001 | 9.4 | Ki | ChEMBL;BindingDB |
| P32745 | SSTR3 | Homo sapiens | Human | PF00001 | 9.3 | Ki | ChEMBL;BindingDB |
| P30872 | SSTR1 | Homo sapiens | Human | PF00001 | 9.1 | Ki | ChEMBL;BindingDB |
| P31391 | SSTR4 | Homo sapiens | Human | PF00001 | 8.9 | Ki | ChEMBL;BindingDB |
DrugBank Target Actions (9)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P08684 | CYP3A4 | Cytochrome P450 3A4 | inhibitor | enzymes |
| P30872 | SSTR1 | Somatostatin receptor type 1 | agonist | targets |
| P30874 | SSTR2 | Somatostatin receptor type 2 | agonist | targets |
| P31391 | SSTR4 | Somatostatin receptor type 4 | agonist | targets |
| P32745 | SSTR3 | Somatostatin receptor type 3 | agonist | targets |
| P35346 | SSTR5 | Somatostatin receptor type 5 | agonist | targets |
| P35372 | OPRM1 | Mu-type opioid receptor | inhibitor | targets |
| P41143 | OPRD1 | Delta-type opioid receptor | inhibitor | targets |
| P08183 | ABCB1 | ATP-dependent translocase ABCB1 | substrate | transporters |