Molecule Details
InChIKeyNHXLMOGPVYXJNR-ATOGVRKGSA-N
Compound NameSomatostatin
Canonical SMILESC[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)5
Pfam Stratification Homologous
Avg pChEMBL9.36
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB09099
Drug NameSomatostatin
CAS Number38916-34-6
Groups approved investigational withdrawn
ATC Codes H01CB01
DescriptionSomatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues [T28] that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and glucagon, and is also generated in the ...

Categories: Amino Acids, Peptides, and Proteins Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 Enzyme Inhibitors Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hypothalamic Hormones Nerve Tissue Proteins Neuropeptides P-glycoprotein substrates Pancreatic Hormones Peptide Hormones Peptides Pituitary Hormone Release Inhibiting Hormones Pituitary and Hypothalamic Hormones and Analogues Proteins Somatostatin and Analogues Somatostatin, agonists Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins
Cross-references: BindingDB: 81767 ChEBI: 64628 CHEMBL1823872 ChemSpider: 17286507 Drugs Product Database (DPD): 11700 D07431 PubChem:16129681 PubChem:310265025 RxCUI: 9939 Wikipedia: Somatostatin
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
P30874 SSTR2 Homo sapiens Human PF00001 10.1 Ki ChEMBL;BindingDB
P35346 SSTR5 Homo sapiens Human PF00001 9.4 Ki ChEMBL;BindingDB
P32745 SSTR3 Homo sapiens Human PF00001 9.3 Ki ChEMBL;BindingDB
P30872 SSTR1 Homo sapiens Human PF00001 9.1 Ki ChEMBL;BindingDB
P31391 SSTR4 Homo sapiens Human PF00001 8.9 Ki ChEMBL;BindingDB
DrugBank Target Actions (9)
Target Gene Target Name Action Type
P08684 CYP3A4 Cytochrome P450 3A4 inhibitor enzymes
P30872 SSTR1 Somatostatin receptor type 1 agonist targets
P30874 SSTR2 Somatostatin receptor type 2 agonist targets
P31391 SSTR4 Somatostatin receptor type 4 agonist targets
P32745 SSTR3 Somatostatin receptor type 3 agonist targets
P35346 SSTR5 Somatostatin receptor type 5 agonist targets
P35372 OPRM1 Mu-type opioid receptor inhibitor targets
P41143 OPRD1 Delta-type opioid receptor inhibitor targets
P08183 ABCB1 ATP-dependent translocase ABCB1 substrate transporters