Molecule Details
| InChIKey | NGVJHXBKRDWBLJ-DEOSSOPVSA-N |
|---|---|
| Compound Name | 5-[2-(5-chloro-2-hydroxyphenyl)-5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-pyridinyl]-1,3-dihydroindol-2-one |
| Canonical SMILES | O=C1Cc2cc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)ccc2N1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.69 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 7.0 | IC50 | ChEMBL;BindingDB |
| P21802 | FGFR2 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 6.8 | IC50 | ChEMBL;BindingDB |
| P22607 | FGFR3 | Homo sapiens | Human | PF21165 PF07679 PF13927 PF07714 | 6.2 | IC50 | ChEMBL;BindingDB |