Molecule Details
| InChIKey | NGLYSTCXIRGOIR-UHFFFAOYSA-N |
|---|---|
| Compound Name | N-(3,5-dichloro-4-pyridinyl)-2-[3-[(4-hydroxyphenyl)methyl]indolizin-1-yl]-2-oxoacetamide |
| Canonical SMILES | O=C(Nc1c(Cl)cncc1Cl)C(=O)c1cc(Cc2ccc(O)cc2)n2ccccc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.82 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 7.8 | IC50 | ChEMBL |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 7.8 | IC50 | ChEMBL |
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 7.8 | IC50 | ChEMBL |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 7.8 | IC50 | ChEMBL |