Molecule Details
InChIKeyNFMGZVPRGVERNN-UHFFFAOYSA-N
Compound NameN-[3-[5-[2-[3-(2-oxopyrrolidin-1-yl)anilino]pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide
Canonical SMILESO=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)44
Pfam Stratification Cross-Family
Avg pChEMBL6.89
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (44)
Target Gene Organism Category Pfam pChEMBL Type Source
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 8.4 Ki ChEMBL
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 8.4 Ki ChEMBL
Q15303 ERBB4 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 8.3 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 8.0 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.9 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 7.9 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 7.9 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 7.8 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.7 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.7 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.7 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.5 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.5 Ki ChEMBL
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 7.4 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.3 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.3 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.2 Ki ChEMBL
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 7.0 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.9 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.8 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.6 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.6 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.6 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.5 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.3 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.2 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q9H3Y6 SRMS Homo sapiens Human PF07714 PF00017 6.2 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.1 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 6.1 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 6.1 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.0 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.0 Ki ChEMBL
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 6.0 Ki ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.0 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.0 Ki ChEMBL
Q9BXA7 TSSK1B Homo sapiens Human PF00069 6.0 Ki ChEMBL