N-{4-Methyl-3-[(3-pyrimidin-4-ylpyridin-2-YL)amino]phenyl}-3-(trifluoromethyl)benzamide — MultiTargetDB

Molecule Details

InChIKey	`NESXBRNDMQUVNG-UHFFFAOYSA-N`
Compound Name	N-{4-Methyl-3-[(3-pyrimidin-4-ylpyridin-2-YL)amino]phenyl}-3-(trifluoromethyl)benzamide
Canonical SMILES	`Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncccc1-c1ccncn1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	7.49
Source	ChEMBL;BindingDB

2D Structure

2D structure

Activity Profile

DrugBank Annotations

DrugBank ID	DB08221
Drug Name	N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE
CAS Number	nan
Groups	experimental
ATC Codes	nan
Description	nan

Cross-references: BindingDB: 50207861 CHEMBL245549 ChemSpider: 13168828 PDB: MUH PubChem:16040281 PubChem:99444692 ZINC: ZINC000008582034

Target Activities (2)

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q02763	TEK	Homo sapiens	Human	PF00041 PF10430 PF07714	7.8	IC50	ChEMBL;BindingDB
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	7.2	IC50	ChEMBL;BindingDB

DrugBank Target Actions (1)

Target	Gene	Target Name	Action	Type
Q02763	TEK	Angiopoietin-1 receptor	binder	targets