InChIKey	NCNRHFGMJRPRSK-MDZDMXLPSA-N
Compound Name	Belinostat
Canonical SMILES	O=C(/C=C/c1cccc(S(=O)(=O)Nc2ccccc2)c1)NO
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	14
Pfam Stratification	Cross-Family
Avg pChEMBL	7.88
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB05015
Drug Name	Belinostat
CAS Number	866323-14-0
Groups	approved investigational
ATC Codes	L01XH04
Description	Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use...

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Categories: Amides Amines Antineoplastic Agents Antineoplastic and Immunomodulating Agents Cancer immunotherapy Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (weak) Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (weak) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Enzyme Inhibitors Histone Deacetylase Inhibitors Histone deacetylase (HDAC) inhibitors Hydroxy Acids Hydroxylamines Immunosuppressive Agents Immunotherapy Myelosuppressive Agents Narrow Therapeutic Index Drugs P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Sulfones Sulfur Compounds UGT1A1 Substrates UGT1A1 Substrates with a Narrow Therapeutic Index

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Cross-references: BindingDB: 25150 ChEBI: 61076 CHEMBL408513 ChemSpider: 5293831 PDB: 5OG PubChem:6918638 PubChem:347827703 RxCUI: 1543543 Wikipedia: Belinostat ZINC: ZINC000003818726