Molecule Details
| InChIKey | NBGABHGMJVIVBW-QHCPKHFHSA-N |
|---|---|
| Canonical SMILES | COc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@]2(C)c2nc3c(C)c(Cl)ccc3[nH]2)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.61 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB15031 |
|---|---|
| Drug Name | Daridorexant |
| CAS Number | 1505484-82-1 |
| Groups | approved investigational |
| ATC Codes | N05CJ03 |
| Description | Daridorexant, formerly known as nemorexant, is a selective dual orexin receptor antagonist used to treat insomnia. Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning. It chronically affects the person's daily functioning and long... |
Categories: Central Nervous System Depressants Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Hypnotics and Sedatives Nervous System Orexin Receptor Antagonists Psycholeptics Wakefulness-Promoting Agents
Cross-references: BindingDB: 334973 CHEMBL4297590 ChemSpider: 64854514 Drugs Product Database (DPD): 23835 PDB: NS2 RxCUI: 2591497 Wikipedia: Daridorexant