N-[4-(5-chloro-1,3-benzothiazol-2-yl)phenyl]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-amine

InChIKey	`NACVPONJWZPHAP-UHFFFAOYSA-N`
Compound Name	N-[4-(5-chloro-1,3-benzothiazol-2-yl)phenyl]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-amine
Canonical SMILES	`COc1cc2c(Nc3ccc(-c4nc5cc(Cl)ccc5s4)cc3)ncnc2cc1OCCCN1CCN(C)CC1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	5
Pfam Stratification	Cross-Family
Avg pChEMBL	6.99
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O14965	AURKA	Homo sapiens	Human	PF00069	7.6	IC50	ChEMBL;BindingDB
O75716	STK16	Homo sapiens	Human	PF00069	7.2	pIC50	TTD_MultiTarget
Q96GD4	AURKB	Homo sapiens	Human	PF00069	7.2	IC50	ChEMBL;BindingDB
Q02763	TEK	Homo sapiens	Human	PF00041 PF10430 PF07714	6.7	pIC50	TTD_MultiTarget
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.2	IC50	ChEMBL;BindingDB